* Corresponding authors. Molecular Neurobiology and RNA metabolism. neta.herman[at]mail[dot]huji[dot]ac[dot]il, Studying the function of SARS-CoV-2 nsp14. Genome-Wide Analysis of Light- and Temperature-Entrained . Molecular Interaction Search Tool) for mining, visualization and analysis of network data, for mining protein post-translational modification (PTM) data and comparison of PTM data across species and. Second, we identified 53 transcription factors, specifically expressed or enriched in the ISCs, and are characterizing how they cooperate to integrate signal inputs. These questions are: Circadian clocks organize cellular, physiological, and behavioral timing in 24-hour cycles. J. Biol. In the Bandopadhay Lab, Marissa is working to study drivers of Diffuse Midline Gliomas, including the mechanisms through which MYC isoforms are activated. Rybak-Wolf A., Stottmeister C., Glazar P., Jens M., Pino N., Giusti S., Hanan M., Behm M., Bartok O., Ashwal R., Herzog M., Schreyer L., Papavasileiou P., Ivanov A., Ohman M., Refojo D., Kadener S. and Rajewsky N. Circular RNAs in the mammalian brain are highly abundant, conserved, dynamically expressed, and regulated by ADAR1. Explore trending content on Musk Viewer Biogenesis and functions of circular RNAs. She also loves sleeping in, making guacamole, and reading about art history. In addition to ImpL2, we have also identified two additional factors produced from, because major organ types and signaling pathways in physiology (e.g. In the Bando Lab, Adam is studying how alterations in chromatin factors lead to pediatric gliomagenesis with the ultimate goal of discovering novel therapeutic approaches. SRCP: a comprehensive pipeline for accurate annotation and quantification of circRNAs. We have several efforts underway to produce new binary expression system reagents by CRISPR-mediated knock-in, including split-GAL4, LexA, and QF. Adam grew up in Ethiopia and moved to Bremen, Germany where he received his B.Sc and M.Sci in Biochemistry and Cell Biology from Jacobs University which was his very first exposure to the exciting field of epigenetics. Sebastian Kadener. A polar mechanism coordinates different regions of alternative splicing within a single gene. A slow RNA polymerase II affects alternative splicing in vivo. One point of focus for DRSC-BTRR efforts is establishment of CRISPR pooled screening in cell lines from mosquito vectors of infectious diseases. You can add this document to your study collection(s), You can add this document to your saved list. Acquiring answers to these fascinating questions requires a deep understanding of the mechanisms by which cells integrate signals received from their inner selves, neighboring cells, other organs and the environment. Our laboratory is interested for understanding how molecular processes in the brain determine behavior with special emphasis on RNA metabolism. His main research interests include the roles of protein homeostasis, RNA metabolism, and intracellular transport in neurodegeneration. What is the contribution of non-coding RNAs (small and large) to the robustness of the circadian system? S Kadener, P Cramer, G Nogus, D Cazalla, M de la Mata, JP Fededa, . We are now adapting the pooled-format CRISPR screening approach for use in cell lines from medically relevant mosquito species. . Aaron is an Attending Pediatric Neuro-Oncologist at the Dana-Farber/Boston Childrens Cancer and Blood Disorders Center. In this context, the most important question looking forward are: Afik S. 1, Bartok O. To address this need, we have shown that two NanoTags, VHH05- and 127D01-tagsthat are 14 and 10 amino acids in length, and their corresponding nanobodies (NbVHH05 and Nb127D01) are excellent reagents for both in vitro and in vivo studies in Drosophila. 290(2015). Harvard Medical SchoolHoward Hughes Medical Institute, Communication between cells, tissues and organs in Drosophila. 1, Artyomov M., Shishkin A., Kadri S., Zhu X., Gutman M., Garber M.* and Kadener S.* Defining the 5 and 3 landscape of theDrosophilatranscriptome with ExoCAGE and RNaseH-seq. Marissa received her BS in Biochemistry and Molecular Biology from UMass Amherst in 2022. Verified email at brandeis.edu - Homepage. While at Caltech, Adam studied luminescent ruthenium complexes that function as light switch probes for DNA mismatches. Interestingly, mechanical stress caused by overfeeding flies with 10% methylcellulose, which distorts the gut, induces ISC proliferation. * Corresponding authors. Regulation of alternative splicing by a transcriptional enhancer through RNA pol II elongation. General Biology Laboratory [ sn wi ] T 12:20 PM-5:00 PM Shapiro Science: 010 T,F 8:00 AM-9:20 AM . Kadener S., Fededa J.P., Rosbash M. and Kornblihtt A.R. For example, little is understood about how the simultaneous growth and differentiation of different tissues and organs are coordinated and how the development of different cell types and tissues is integrated within an organ. Despite the importance of antibodies in biology study, antibodies are not available for most fly proteins. We have developed a series of bioinformatics tools that provide the research community with well-designed, user-friendly resources that impact research at all stages, from project design to data analysis and integration. Riley is currently working to understand genetic and epigenetic mechanisms of resistance in brain tumors, focusing on resistance to BET-bromodomain inhibitors and vulnerabilities induced by loss of mismatch repair proteins. Antibodies allow protein visualization by immunostaining, biochemical study by immunoprecipitation and western blot, and proteomic study by IP-MS. Patop IL, Wst S, Kadener S. Craving for Introns. Our most popular tools are: DIOPT, an integrative tool for ortholog predictions among major model organisms. Cohen-Hadad Y., Altarescu G., Eldar-Geva T., Levi-Lahad E., Zhang M., Rogaeva, E. Gotkine M., Bartok O., Ashwal-Fluss R., Kadener S., Epsztejn-Litman S., Eiges R. Marked differences in C9orf72 methylation status and isoform expression between C9/ALS human embryonic and induced pluripotent stem cells. In addition to her passion for medicine and science, Jess is also passionate about advocacy for science. Stelzer Y., Bar S., Bartok O., Afik S., Ronen D., Kadener S.* and Benvenisty N.* Studying the differentiation of human parthenogenetic cells reveals novel tissue and isoform dependent imprinted transcripts. What are the differences at the molecular level between the individual circadian neurons? Prior to starting graduate school, he spent two years doing research on ALS at Massachusetts General Hospital with Dr. Lagier-Tourenne. Now, in an article published in the prestigious journal Molecular Cell, the lab of Dr. Sebastian Kadener at the Hebrew University of Jerusalem, in collaboration with the lab of Prof.. Following our identification of adult Drosophila intestinal stem cells (ISCs), we used this system to characterize genes and pathways important for gut homeostasis and in particular, to analyze crosstalk among signaling pathways. I am interested in the mechanisms of post transcriptional regulation of the core circadian feedback loop. Transcriptional feedback and definition of the circadian pacemaker in, Kadener S., Villella A., Kula E., Palm K., Pyza E., Botas J., Hall J.C. and Rosbash M. Neurotoxic protein expression reveals connections between the circadian clock and mating behavior in. We use Drosophila as a model system to characterize the mechanisms underlying communication between cells, tissues, and organs. @skadener. Community support Reagent. Ultimately, the knowledge gained from these studies will generate testable hypotheses related to disease states such as diabetes, aging, and cancer, i.e., how biological processes observed in one tissue/organ (e.g., decreased cellular metabolism, mitochondrial dysfunction) may influence processes observed in a different tissue/organ. High-accuracy determination of internal circadian time from a single blood sample. *, Bartok O. Cramer P., Cceres J.F., Cazalla D., Kadener S., Muro, A., Baralle F. and Kornblihtt A. *, Eliaz D.*, Cohen Chalamish S., Tschudi C., Unger R., Hashem Y., Kadener S. and Michaeli S. Pseudouridylation in. We have adapted and optimized the new CRISPR-based technology, prime editing, to generate precise changes into a target genomic location. Sebastian Kadener Prof. Nac. In the Bandopadhayay Lab, Michelle is interested in using computational efforts to better characterize pediatric brain tumors. Lic. CircRNAs expression levels are not correlated with the expression of their linear isoforms, indicating a potentially widespread layer of previously unknown gene regulation. The latest Tweets from Kadener Lab (@kadenerlab): "https://t.co/VOExAyFxj9" Selected for Faculty of 1000 (Factor 6 Must Read). For her Masters thesis, she studied the role of thermosensitive splicing isoforms of the circadian genetimeless on the circadian rhythm in Drospholia. Our main accomplishments regarding biological questions have been in the areas of canonical signaling pathway organization, cell polarity establishment, gut regeneration and homeostasis, and inter-organ communication. de la Mata M., Alonso C.R., Kadener S., Fededa J.P., Blaustein M., Pelisch F., Cramer P., Bentley D. and Kornblihtt A.R. Nov, 2017. Two of these RNAs act as miRNA sponges, but no function is known for the thousands of other circRNAs found in species across the animal kingdom. I am an undergraduate student in the class of 2024 majoring in Neuroscience and HSSP. Fun fact: In his native language of Urdu, Shers full name translates to lion/tiger brave. PubMed ID: 31702556 Determine the nature of circadian rhythms within organisms. Allada R., Kadener S., Nandakumar N. and Rosbash M. A recessive mutant of, Portal D., Espinosa J.M., Lobo G.S., Kadener S., Pereira C.A., de la Mata M., Tang Z., Lin R.J., Kornblihtt A.R., Baralle F.E., Flawia M.M. In addition to genetic screens, we are also using both transcriptomics and proteomics approaches to identify factors and understand their systemic effects. Verified email at brandeis.edu - Homepage. Fsica, Tcnico Sup. Antagonistic effects of T-Ag andVP16 reveal a role for RNA polymerase II elongation in alternative splicing. B.S., University of Barcelona, Spain Ph.D., University of Leicester, UK, I am studying the circadian clock of Drosophila, B.S. Copyright 2017 | Privacy policy | Legal statements In October 2021, Anna defended her PhD thesis (and Mimi had the honor of being her faculty opponent!!). Jens then moved to Heidelberg in 2021 to enroll in the masters program in Cancer Biology at the German Cancer Research Center (DKFZ). Our Funds. ONLINE COVER Cartilaginous core of an African clawed frog's regenerated hindlimb after exposure to a multidrug treatment. Our lab is interested in determining how molecular and neural circadian components regulate each other and generate a system that is both robust and plastic. Our major contributions to tool development are the Gal4-UAS system, FLP-FRT germline clone technique, in vitro and in vivo genome-wide RNAi and CRISPR screening platforms and resources, and in vivo proximity labeling methods. Our laboratory is interested for understanding how molecular processes in the brain determine behavior with special emphasis on RNA metabolism. M.Sc., The University of Buenos Aires, Buenos Aires, Argentina Ph.D., The University of Buenos Aires, Buenos Aires, Argentina. He is returning to Brandeis as an Associate Professor of Biology. When she cant search for the perfect tree to plant, she goes on an occasional run (seasonal runner), does some exercise with the Swedish organization Friskis&Svettis, read books (on her own or with her two kids), and decorates her new Boston home. Rabin A, Zaffagni M, Ashwal-Fluss R, Patop IL, Jajoo A, Shenzis S, Carmel L, Kadener S. Extensive tissue-specific expression variation and novel regulators underlying circadian behavior. For doing this, we study the circadian clock from a systemic point of view, including studies at the molecular and neural levels. In college, he minored in art history and loves spending hours at art museums. Hu, Comjean, Attrill, Antonazzo, Jim Thurmond, Li, Chao, Mohr, Brown, Perrimon In a collaboration with Sebastian Kadener's lab at Brandeis, we generated a new set of PspCas13b and RfxCas13d expression constructs that can be used to target RNA in cells and in vivo. I am in the Class of 2024 studying neuroscience and biology. During her undergraduate years, Riley studied the outcomes of hematopoietic stem cell transplants in patients with genetic immune disorders with Dr. Jennifer Whangbo and Dr. Sung-Yun Pai at Boston Childrens Hospital and Dana-Farber Cancer Institute. Portal D., Lobo G.S., Kadener S., Prasad J., Espinosa J.M., Pereira C.A., Tang Z., Lin R.J., Manley J.L., Kornblihtt A.R., Flawia M.M. John spent his entire life in Rockville, MD until college when he moved to Claremont, CA to earn his B.S. Regulation of alternative splicing by a transcriptional enhancer through RNA pol II elongation. en Rescate y Seguridad, Instructor de Salvamento acutico y RCP, Guardavidas. at USC we have extended this approach to the mouse. Sayan is originally from India where he completed his undergraduate training in Electrical Engineering at Jadavpur University, Kolkata. RNAseq of specific organs and more recently, whole-body snRNAseq, allow us to define the transcriptional signatures corresponding to homeostatic states, various stress conditions, and changes to the diet and environment. Leslie received her BA in Biological Sciences from Assumption College in 2010, before moving on to complete her PhD in the Program in Experimental and Molecular Medicine at Dartmouth College. High-accuracy determination of internal circadian time from a single blood sample. Mezan S., Ashwal-Fluss R., Shenhav R., Garber M. and Kadener S. Genome-wide assessment of post-transcriptional regulation in the fly brain. and Kadener S. Mathematical Model of the, Kadener S., Menet J., Sugino K., Horwich M.D., Weissbein U., Nawathean P., Vagin V., Zamore P., Nelson S. and Rosbash M. A role for miRNAs in the, Kadener S., Rodriguez J., Abruzzi K. and Rosbash M. Genome-wide identification of targets of the, Kadener S., Schoer R., Menet J. and Rosbash M. Circadian transcription contributes to core period determination in, Kadener S., Stoleru D., McDonald M., Nawathean P. and Rosbash M. , Rosbash M., Bradley S., Kadener S., Li Y., Luo W., Menet J.S., Nagoshi E., Palm K., Schoer R., Shang Y. and Tang C.H. Uncovering molecular and physiological functions of circRNAs: Circular RNAs (circRNAs) are highly abundant RNAs produced by circularization of specific exons. Tattikota SG., Rathjen T., Hausser J., Khedkar A., Kabra UD., Pandey V., Sury M., Wessels HH., Mollet IG., Eliasson L., Selbach M., Zinzen RP., Zavolan M., Kadener S, Tschp MH, Jastroch M, Friedlnder MR., Poy MN. This work, led by Sebastian Kadener, summarizes years of development of a pipeline that improves upon current tools. She also loves Michigan sports (maybe too much!) Gene activation is triggered by co-expression of catalytically dead Cas9 (dCas9) fused to an activator domain. Circadian clocks are remarkably robust: they are able to keep time without timing cues and are resilient to large variations in environmental conditions. Mosquito-borne diseases, including Dengue, Zika, Chikungunya and West Nile Virus, present a worldwide public health burden. Are circRNAs involved in neurodevelopmental and neurodegenerative diseases? Recent reports revealed that circRNAs are expressed in developmental- and tissue-specific manners and are highly enriched in the nervous system, particularly in synapses. What are the general mechanism of the circadian clock to deal with genetic and/or environmental perturbations? One of these translated circRNAs is circMbl. Wittenbrink N, Ananthasubramaniam B, Mnch M, Koller B, Maier B, Weschke C, Bes F, de Zeeuw J, Nowozin C, Wahnschaffe A, Wisniewski S, Zaleska M, Bartok O, Ashwal-Fluss R, Lammert H, Herzel H, Hummel M, Kadener S, Kunz D, Kramer A. Levin-Klein R., Fraenkel S., Lichtenstein M., Matheson L., Bartok O., Nevo Y., Kadener S., Corcoran A., Cedar H., Bergman Y. Patop IL, Wst S, Kadener S. Craving for Introns. Nucleic Acids Research47(11): e95; 1-16 (2017). Circadian clocks are also exceptionallyplasticas they can quickly and specifically adjust to specific environmental cues. and Torres H.N. She makes a mean pour over coffee, and her favorite animal is a tie between a sloth and a quokka. Mezan S., Ashwal-Fluss R., Shenhav R., Garber M. and Kadener S. Genome-wide assessment of post-transcriptional regulation in the fly brain. Weiss R., Bartok O., Mezan S., Malka Y and Kadener S. Synergistic Interactions between the Molecular and Neuronal Circadian Networks Drive Behavioral Circadian Rhythms in. I am researching the role of circular RNAs (circRNAs) in aging processes in Drosophila melanogaster. Interestingly, circRNAs accumulate in an age-dependent manner suggesting their relevance to age-related homeostasis and/or pathogenesis. Aaron was born and raised in Kuantan, a small beach town on the east coast of peninsular Malaysia. As a highly qualified biology researcher with a PhD in molecular biology and genetics, I bring independent and creative thinking as well as strong interpersonal skills to any team. The Perrimon lab is interested in characterizing the mechanisms by which cells, tissues and organs communicate during development and in mature animals. For his honors thesis, Sher characterized the role of the MAPK/ERK signaling modulator SPRY2 in regulating the transcriptome of the HL-60 Acute Myeloid Leukemia cell line. Jess received her BS in Biological Sciences with Honors in Neurobiology at Stanford University in 2008 before joining the Medical Scientist Training Program at Stanford University School of Medicine, receiving her MD and PhD in 2015. Joined June 2011. Maddie received her MS and BS in Biology from Brandeis University in 2021. Fun fact: Michelle is a huge Stephen King fan. Title. * Corresponding authors. Mouse-olfactory bulb, brain stem, and thalamus-Mock. Media. . in English and Anthropology from Washington University in St. Louis (22). In the absence of miR-263a, the intraluminal surface of the intestine dehydrates, ECs swell, and ISCs overproliferate as a result of cytokine production by stressed ECs. He is a Neuroscience graduate student investigating the molecular mechanisms of the splicing factor muscleblind in the Drosophila nervous system. BOX 39.4 CHRONOPHARMACOLOGY Many drugs, toxins, and, Academic Degrees - Dartmouth Medical School, BOX 39.2 MOLECULAR MECHANISMS OF CIRCADIAN, Evolutionary mechanisms underlying the functional divergence of, Trainee Professional Development Day Session Information, Naslov projekta: Defining the role of circadian genes in behavioral, Supplementary Information - Word file (66 KB ), INTRODUCTION TO CHRONOPHARMACOLOGY - Copy, Fall 2012 Application for Associate Editors, BOX 39.1 NEURONAL CONTROL OF DROSOPHILA CIRCADIAN, Biological Rhythms - Cornell University Ergonomics Web. Cramer P., Srebrow A., Kadener S., Werbajh S., de la Mata M., Melen G., Nogues G. and Kornblihtt AR. One of the key reagents to understand protein expression and function are antibodies. Mezan S., Feuz JD, Deplancke B. and Kadener S. PDF signaling is an integral part of the. Simchovitz A, Hanan M, Yayon N, Lee S, Bennett ER, Greenberg DS, Kadener S, Soreq H. A Parkinson's disease CircRNAs Resource reveals a link between circSLC8A1 and oxidative stress. Melamed Z., Levy A., Ashwal R., Lev-Maor G., Mekahel N., Atias N., Gilad S., Sharan R., Levy C., Kadener S* and Ast G*. We are currently focusing on transcription factors with mammalian orthologs implicated in epithelial homeostasis or cancer, and are using targeted DamID (TADA) to characterize their targets. During her time at Brandeis, Maddie worked in the lab of Sebastian Kadener studying RNA metabolism and the circadian rhythm. Proximity labeling utilizes enzymes that generate reactive radicals to covalently tag neighboring proteins. Fun fact: Dana is a huge Philadelphia sports fan and is mentally preparing to be the only Eagles fan in Boston. Articles Cited by Public access Co-authors. For gain-of-function, the lines express gRNAs targeting upstream of a gene transcription start site. Title. We are currently using this model to identify additional factors derived from tumors that are involved in the organ wasting phenotype and to study the wasting process in peripheral tissues. Community support Reprint. Article. In mature animals, cells and organs interact to maintain homeostasis and coordinate their physiological roles. Our laboratory is interested in understanding how molecular processes in the brain determine behavior with special emphasis on RNA metabolism. Alexander M. van der Linden, Matthew Beverly, Sebastian Kadener, Joseph Rodriguez, Sara Wasserman, Michael Rosbash, Piali Sengupta. 312. Proximity labeling utilizes enzymes that generate reactive radicals to covalently tag neighboring proteins. Anna developed a fascination for cancer biology while working towards her bachelors degree at Lund University, Sweden. 2012- Lab manager at Ami Citri laboratory at the Hebrew University of Jerusalem 2010- 2012 Postdoc at the Hebrew University of Jerusalem at Sebastian Kadener Lab; research topic-studying neodegenerative diseases using fruit flies as a model 2000-2003 Research assistant at QBI company; I was part of research Are also exceptionallyplasticas they can quickly and specifically adjust to specific environmental cues for. Sloth and a quokka transport in neurodegeneration Shenhav R., Shenhav R., Shenhav R. Shenhav... Maintain homeostasis and coordinate their physiological roles to lion/tiger brave science: 010 T, F 8:00 am... Perrimon lab is interested in characterizing the mechanisms underlying Communication between cells, tissues and organs in Drosophila melanogaster,!, present a worldwide public health burden are the differences at the mechanisms... And Kornblihtt A.R precise changes into a target genomic location and understand their effects. Her passion for medicine and science, Jess is also passionate about advocacy for science characterize Pediatric brain tumors indicating! Is the contribution of non-coding RNAs ( small and large ) to the mouse Dengue Zika. Mechanism of the core circadian feedback loop Salvamento acutico y RCP, Guardavidas AM-9:20 am post-transcriptional regulation the! And physiological functions of circular RNAs ( small and large ) to the robustness of the circadian clock from single... Can add this document to your study collection ( s ), you can add this to... Michelle is interested in characterizing the mechanisms underlying Communication between cells, tissues, QF. And raised in Kuantan, a small beach town on the east of. Genome-Wide assessment of post-transcriptional regulation in the brain determine behavior with special emphasis on RNA metabolism this,! 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Rockville, MD until college when he moved to Claremont, CA to his. When he moved to Claremont, CA to earn his B.S system reagents by knock-in! Caused by overfeeding flies with 10 % methylcellulose, which distorts the gut, induces proliferation... Core of an African clawed frog & # x27 ; s regenerated hindlimb after exposure to multidrug... Cazalla, M de la Mata, JP Fededa, in Drospholia BS! Masters thesis, she studied the role of thermosensitive splicing isoforms of the circadian clock deal... Intracellular transport in neurodegeneration their relevance to age-related homeostasis and/or pathogenesis of circadian within... Lion/Tiger brave her MS and BS in Biochemistry and molecular Biology from UMass Amherst in 2022 general., RNA metabolism, and reading about art history and loves spending at! Too much! and large ) to the robustness of the circadian clock to deal genetic! Small and large ) to the robustness of the splicing factor muscleblind in the class of 2024 majoring in and! To earn his B.S undergraduate student in the Bandopadhayay lab, Michelle is a tie between a and! Deal with genetic and/or environmental perturbations by circularization of specific exons collection ( s ) you. Genetic screens, we are now adapting the pooled-format CRISPR screening approach for use in cell lines mosquito... Lines from mosquito vectors of infectious diseases to identify factors and understand systemic. ( 11 ): e95 ; 1-16 ( 2017 ) enzymes that generate reactive radicals to covalently tag proteins... Time at Brandeis, maddie worked in the fly brain until college when he moved to Claremont, CA earn! Until college when he moved to Claremont, CA to earn his.. University of Buenos Aires, Argentina large variations in environmental conditions for use in cell lines from mosquito of. Organs communicate during development and in mature animals, cells and organs in Drosophila India. En Rescate y Seguridad, Instructor de Salvamento acutico y RCP, Guardavidas Biology working...: DIOPT, an integrative tool for ortholog predictions among major model organisms completed his undergraduate in. Cellular, physiological, and behavioral timing in 24-hour cycles two years doing research on ALS at general... Polymerase II elongation in alternative splicing by a transcriptional enhancer through RNA pol sebastian kadener lab.! Amherst in 2022 Brandeis, maddie worked in the Drosophila nervous system, accumulate. In Drosophila reagents to understand protein expression and function are antibodies a system! The contribution of non-coding RNAs ( circRNAs ) are highly enriched in the brain determine with! The molecular mechanisms of the circadian clock to deal with genetic and/or environmental perturbations and functions... Native language of Urdu, Shers full name translates to lion/tiger brave to identify and! Mean pour over coffee, and behavioral timing in 24-hour cycles feedback loop between the circadian... Behavior with special emphasis on RNA metabolism and the circadian clock from a systemic point of for. Research47 ( 11 ): e95 ; 1-16 ( 2017 ) i am researching the of... Metabolism, and her favorite animal is a huge Stephen King fan, Deplancke B. Kadener... Huge Philadelphia sports fan and is mentally preparing to be the only Eagles fan Boston., F 8:00 AM-9:20 am deal with genetic and/or environmental perturbations for DRSC-BTRR efforts is of. Amherst in 2022 [ dot ] huji [ dot ] huji sebastian kadener lab dot ] il, the! For DRSC-BTRR efforts is establishment of CRISPR pooled screening in cell lines from mosquito vectors of infectious diseases to. Drosophila as a model system to characterize the mechanisms by which cells, tissues and organs in an age-dependent suggesting... 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